As the world's climate patterns continue to shift unpredictably, places where drinking water was once abundant may soon find reservoirs dry and groundwater aquifers depleted. In this talk, civil and environmental engineer David Sedlak shares four practical solutions to the ongoing urban water crisis. His goal: to shift our water supply towards new, local sources of water and create a system that is capable of withstanding any of the challenges climate change may throw at us in the coming years.

Inventor and MacArthur fellow Saul Griffith shares some innovative ideas from his lab -- from "smart rope" to a house-sized kite for towing large loads.

Current medical treatment boils down to six words: Have disease, take pill, kill something. But physician Siddhartha Mukherjee points to a future of medicine that will transform the way we heal.

Imagine being unable to say, "I am hungry," "I am in pain," "thank you," or "I love you,” -- losing your ability to communicate, being trapped inside your body, surrounded by people yet utterly alone. For 13 long years, that was Martin Pistorius’s reality. After contracting a brain infection at the age of twelve, Pistorius lost his ability to control his movements and to speak, and eventually he failed every test for mental awareness. He had become a ghost. But then a strange thing started to happen -- his mind began to knit itself back together. In this moving talk, Pistorius tells how he freed himself from a life locked inside his own body.

Twenty-three Grand Slam titles later, tennis superstar Serena Williams sits down with journalist Gayle King to share a warm, mischievous conversation about her life, love, wins and losses -- starting with the story of how she accidentally shared her pregnancy news with the world.

"In the cathedral of the wild, we get to see the best parts of ourselves reflected back to us." Boyd Varty, a wildlife activist, shares stories of animals, humans and their interrelatedness, or "ubuntu" -- defined as, "I am, because of you." And he dedicates the talk to South African leader Nelson Mandela, the human embodiment of that same great-hearted, generous spirit.

This talk begins with a personal story of sexual violence that may be difficult to listen to. But that's the point, says citizen journalist Meera Vijayann: Speaking out on tough, taboo topics is the spark for change. Vijayann uses digital media to speak honestly about her experience of gender violence in her home country of India -- and calls on others to speak out too.

Sarah Kaminsky tells the extraordinary story of her father Adolfo and his activity during World War II -- using his ingenuity and talent for forgery to save lives.

You've heard about slow food. Now here's slow ... TV? In this very funny talk, Norwegian television producer Thomas Hellum shares how he and his team began to broadcast long, boring events, often live -- and found a rapt audience. Shows include a 7-hour train journey, an 18-hour fishing expedition and a 5.5-day ferry voyage along the coast of Norway. The results are both beautiful and fascinating. Really.

Shonda Rhimes, the titan behind Grey's Anatomy, Scandal and How to Get Away With Murder, is responsible for some 70 hours of television per season, and she loves to work. "When I am hard at work, when I am deep in it, there is no other feeling," she says. She has a name for this feeling: The hum. The hum is a drug, the hum is music, the hum is God's whisper in her ear. But what happens when it stops? Is she anything besides the hum? In this moving talk, join Rhimes on a journey through her "year of yes" and find out how she got her hum back.